Harry Coombes is a retired teacher in his 70s who has lived in the Upper West Side of New York City all his life. When his building is torn down to make way for a parking garage, Harry and his beloved cat Tonto begin a journey across the United States — visiting his children, seeing a world he never seemed to have the time to see before, making new friends, and saying goodbye to old friends.
| Actor | Role |
|---|---|
 Art CarneyHarry | Harry |
 Ellen BurstynShirley | Shirley |
 Geraldine FitzgeraldJessie | Jessie |
 Chief Dan GeorgeSam Two Feathers | Sam Two Feathers |
 Larry HagmanEddie | Eddie |
 Philip BrunsBurt | Burt |
 Herbert BerghofRivetowski | Rivetowski |
 Josh MostelNorman | Norman |
 Melanie MayronGinger | Ginger |
| AAvon LongLeroy | Leroy |
 Arthur HunnicuttWade | Wade |
 Barbara RhoadesHooker | Hooker |
| DDolly JonahElaine | Elaine |
 Cliff DeYoungBurt Jr. | Burt Jr. |
| SSybil BowanOld Landlady | Old Landlady |
| SSally MarrCat Lady | Cat Lady |
 René EnríquezGrocery Clerk | Grocery Clerk |
 Cliff NortonUsed Car Salesman | Used Car Salesman |
 Philip RothVegas Gambler | Vegas Gambler |
 Louis GussDominic | Dominic |
 Michael McCleeryMugger | Mugger |
 Rashel NovikoffMrs. Rothman | Mrs. Rothman |
 Joe MaddenPanhandler | Panhandler |
| BBette HowardMorgue Clerk | Morgue Clerk |
| PPatricia FayAirport Security Woman | Airport Security Woman |
| MMuriel BeermanTaxi Driver | Taxi Driver |
| CClint YoungBus Driver | Bus Driver |
| MMichael ButlerHitchhiker | Hitchhiker |
| LLetitia TooleWrong Jessie | Wrong Jessie |
| WW. Benson TerryHer Husband | Her Husband |