Serial killer Keith Jesperson murders at least eight women over a five-year span and taunts authorities with disturbing letters and scribbled confessions signed with a happy face.
| Actor | Role |
|---|---|
 David ArquetteKeith Hunter Jesperson | Keith Hunter Jesperson |
 Gloria ReubenMelinda Gand | Melinda Gand |
 Stefanie von PfettenDiane Loftin | Diane Loftin |
 Melissa M. MontgomeryFelicia Boones | Felicia Boones |
 Em HaineSissy Peyton | Sissy Peyton |
 Jordana LargyCandy | Candy |
 Mittita BarberSummer | Summer |
 Josh BlackerPeter | Peter |
 Crystal MudryRedhead | Redhead |
 Kelly-Ruth MercierDelores Pavlinac | Delores Pavlinac |
 David Allan PearsonDez | Dez |
 Vanessa WalshTaffy | Taffy |
 Peter FlemmingJohn | John |
 Kurt EvansLevi | Levi |
 Daryl ShuttleworthCotton | Cotton |
 Spencer DreverYoung Keith | Young Keith |
 Jody ThompsonCora Jesperson | Cora Jesperson |
 Karyn MottBecky Sue Balling | Becky Sue Balling |
 Peter BryantAgent Phillip Kuttner | Agent Phillip Kuttner |
 Darren MooreBud Skinner | Bud Skinner |
 April TelekWanda | Wanda |
 Chilton CraneJo Peyton | Jo Peyton |
| VValerie Sing TurnerDr. Yanine Tirrell | Dr. Yanine Tirrell |
 Eliza FariaKeith's Daughter | Keith's Daughter |
 Hunter DillonKeith's Son | Keith's Son |
| TTodd DaulbyKeith's Father | Keith's Father |
 Jody ThompsonCora Jesperson | Cora Jesperson |