Sherlock Holmes must track down his nemesis, Professor Moriarty, after the villain kidnaps Holmes' brother, Mycroft. The evil doctor is forcing his captive to decode highly classified military documents.
| Actor | Role |
|---|---|
 Edward WoodwardSherlock Holmes | Sherlock Holmes |
 John HillermanDr. John Watson | Dr. John Watson |
 Anthony AndrewsProf. James Moriarty | Prof. James Moriarty |
 Kim ThomsonSophie DeVere | Sophie DeVere |
 Peter JeffreyMycroft Holmes | Mycroft Holmes |
 Warren ClarkeCol. Gould | Col. Gould |
| TTerence LodgeInspector Lestrade | Inspector Lestrade |
 Christopher FairbankJeremy Stubb | Jeremy Stubb |
| HHarry AudleyRichard Farrington | Richard Farrington |
 David SibleyFinch | Finch |
 John TordoffBerton | Berton |
 Nickolas GraceOberstein | Oberstein |
| MMichael TezcanKasim | Kasim |
 Daniel NewmanWiggins | Wiggins |
 Faith KentMrs Hudson | Mrs Hudson |
 David NealMinister | Minister |
| SSteve EllisPoliceman | Policeman |
| DDavid ArlenPolice Driver | Police Driver |
| GGraham GillBallad Singer | Ballad Singer |
 Jimmy FlintWickes | Wickes |
| RRonald NunneryOld Drunk | Old Drunk |
| GGeoffrey RosePreacher | Preacher |
| PPeter BraceHangman | Hangman |
| HHonora BurkeQueen Victoria | Queen Victoria |