One night, high school student Sho Fukamachi discovers a mysterious metal object. Then in a blinding flash of light, Sho finds that he has accidentally fused with the Guyver, a mecha of mysterious alien design. Now, to save his girlfriend, Mizuki Segawa, along with the entire world, Sho must become the Guyver to fight the Chronos Corporation and their biocreatures, called Zoanoids, who are hell-bent on world domination.
| Actor | Role |
|---|---|
 Yu MizushimaSho Fukamachi / Guyver I (voice) | Sho Fukamachi / Guyver I (voice) |
 Michie TomizawaMizuki Segawa | Mizuki Segawa |
 Keiko TodaValkyria F. Lisker / Guyver II | Valkyria F. Lisker / Guyver II |
 Jun HazumiGenzo Makishima | Genzo Makishima |
 Norio WakamotoNot listed | Not listed |
 Yuji FujishiroNot listed | Not listed |
 Jurota KosugiNot listed | Not listed |