Sean Barker became the unwilling host to an alien bio-armor known as the Guyver. A year ago he destroyed the Kronos Corporation, an organization of mutants who want the Guyver. Now he is trying to find why the Guyver unit forces him to fight and kill evil.
| Actor | Role |
|---|---|
 David HayterSean Barker / The Guyver | Sean Barker / The Guyver |
 Kathy ChristophersonCori Edwards | Cori Edwards |
| BBruno GiannottaCrane | Crane |
| SStuart WeissMarcus | Marcus |
| BBilli LeeMizky | Mizky |
| JJim O'DonoghoeGouo | Gouo |
| JJ.D. SmithDoug | Doug |
| AAlisa MerlineBrandi (voice) | Brandi (voice) |
| WWes DeitrickVolker | Volker |
| VVeronica ReedSten (voice) | Sten (voice) |
| SStephen OprychalBob | Bob |
| AAnn GeorgeGail (voice) | Gail (voice) |
| MMarisa CodyMary (voice) | Mary (voice) |
| KKristin CalkinsLois / Primitive Guyver (voice) | Lois / Primitive Guyver (voice) |
 Christopher MichaelAtkins | Atkins |
| EEllis MooreCrusty Old Man | Crusty Old Man |
| LLisa HannanCop #2 | Cop #2 |