 Burt LancasterMarshal Wyatt Earp | Marshal Wyatt Earp |
 Kirk DouglasDr. John 'Doc' Holliday | Dr. John 'Doc' Holliday |
 Jo Van FleetKate Fisher | Kate Fisher |
 Rhonda FlemingLaura Denbow | Laura Denbow |
 John IrelandJohnny Ringo | Johnny Ringo |
 Lyle BettgerIke Clanton | Ike Clanton |
 Frank FaylenSheriff Cotton Wilson | Sheriff Cotton Wilson |
 Earl HollimanDeputy Sheriff Charles 'Charlie' Bassett | Deputy Sheriff Charles 'Charlie' Bassett |
 Ted de CorsiaShanghai Pierce | Shanghai Pierce |
 Dennis HopperBilly Clanton | Billy Clanton |
 Whit Bissell'Tombstone Epitaph' Editor John P. Clum | 'Tombstone Epitaph' Editor John P. Clum |
 George MathewsGriffin Saloonkeeper John Shanssey | Griffin Saloonkeeper John Shanssey |
 John HudsonVirgil Earp | Virgil Earp |
 DeForest KelleyMorgan Earp | Morgan Earp |
 Martin MilnerJames 'Jimmy' Earp | James 'Jimmy' Earp |
 Kenneth TobeyBat Masterson | Bat Masterson |
 Lee Van CleefEd Bailey | Ed Bailey |
 Joan CamdenBetty Earp | Betty Earp |
 Olive CareyMrs. Clanton | Mrs. Clanton |
 Brian G. HuttonRick | Rick |
 Nelson LeighMayor Kelly | Mayor Kelly |
 Jack ElamTom McLowery | Tom McLowery |
 Don CastleDrunk Cowboy in Longbranch Saloon | Drunk Cowboy in Longbranch Saloon |
 Franklyn FarnumBarfly (uncredited) | Barfly (uncredited) |
 Charles HerbertTommy Earp (uncredited) | Tommy Earp (uncredited) |
 Kenner G. KempCroupier (uncredited) | Croupier (uncredited) |
 Colin KennyBarfly (uncredited) | Barfly (uncredited) |
| BBert StevensParty Guest (uncredited) | Party Guest (uncredited) |
 Arthur ToveyBarfly (uncredited) | Barfly (uncredited) |
| LLeslie SketchleyBarfly (uncredited) | Barfly (uncredited) |
