The film documents, in an often dramatic and humorous fashion, Gray's investigations into alternative medicine for an eye condition (Macular pucker) he had developed.
| Actor | Role |
|---|---|
 Spalding GraySpalding Gray | Spalding Gray |
| MMike McLaughlinSelf - Interviewee | Self - Interviewee |
| MMelissa RobertsonSelf - Interviewee | Self - Interviewee |
| AAlvin HenrySelf - Interviewee | Self - Interviewee |
| AAlyne HargroderSelf - Interviewee | Self - Interviewee |
| BBuddy CarrSelf - Interviewee | Self - Interviewee |
| GGerry UrsoSelf - Interviewee | Self - Interviewee |
| CChris SimmsSelf - Interviewee | Self - Interviewee |
| TTommy StaubSelf - Interviewee | Self - Interviewee |
| FFay L. WooSelf - Interviewee | Self - Interviewee |
| KKirk A. Patrick Jr.Self - Interviewee | Self - Interviewee |