Tension builds as threats are carried out, stakes are raised and communication breaks down. In Los Santos a drive-by shooting in Grove Street Family's territory ignites a series of events in the days leading up to the start of the game.
| Actor | Role |
|---|---|
 Samuel L. JacksonTenpenny (voice) | Tenpenny (voice) |
 Chris PennPulaski (voice) | Pulaski (voice) |
 MC EihtRyder (voice) | Ryder (voice) |
 Jas AndersonOG Loc (voice) | OG Loc (voice) |
 Kid FrostT-Bone (voice) | T-Bone (voice) |
 James WoodsToreno (voice) | Toreno (voice) |
 Faizon LoveSweet (voice) | Sweet (voice) |
 Clifton PowellSmoke (voice) | Smoke (voice) |
 Shaun RyderMaccer (voice) | Maccer (voice) |
 Danny DyerKent Paul (voice) | Kent Paul (voice) |
 William FichtnerRosenberg (voice) | Rosenberg (voice) |
 Frank VincentSalvatore (voice) | Salvatore (voice) |
 Young MaylayCJ (voice) | CJ (voice) |
 Armando RiescoHernandez (voice) (uncredited) | Hernandez (voice) (uncredited) |
 Casey SiemaszkoJohnny Sindacco (voice) (uncredited) | Johnny Sindacco (voice) (uncredited) |
 Yolanda WhitakerKendl (voice) (uncredited) | Kendl (voice) (uncredited) |