Grand Canyon revolved around six residents from different backgrounds whose lives intertwine in modern-day Los Angeles. At the center of the film is the unlikely friendship of two men from different races and classes brought together when one finds himself in jeopardy in the other's rough neighborhood.
| Actor | Role |
|---|---|
 Danny GloverSimon | Simon |
 Kevin KlineMack | Mack |
 Steve MartinDavis | Davis |
 Mary McDonnellClaire | Claire |
 Mary-Louise ParkerDee | Dee |
 Alfre WoodardJane | Jane |
 Jeremy SistoRoberto | Roberto |
 Tina LiffordDeborah | Deborah |
 Patrick MaloneOtis | Otis |
 Sarah TriggerVanessa | Vanessa |
 Randle MellThe Alley Baron | The Alley Baron |
| DDestinee DeWaltKelley | Kelley |
| CCandace MeadClaire's Baby | Claire's Baby |
| LLauren MeadClaire's Baby | Claire's Baby |
 Shaun BakerRocstar | Rocstar |
 K. Todd FreemanWipe | Wipe |
| DDeon SamsJimmy | Jimmy |
 Christopher M. BrownRotor | Rotor |
 Gregg DandridgeEddie | Eddie |
 Branscombe RichmondAce Cop | Ace Cop |
| WWalt JordanDeuce Cop | Deuce Cop |
 Todd AllenMyers | Myers |
 Carole Ita WhiteMorning Nurse | Morning Nurse |
 Basil WallaceInsurance Salesman | Insurance Salesman |
| GGeorgina LindseyCathy Fox | Cathy Fox |
 Jack KehlerSteve Fox | Steve Fox |
 Marley SheltonAmanda | Amanda |
| LLynn SalvatoriWoman In Baseball Cap | Woman In Baseball Cap |
| JJim MorangeBus Driver | Bus Driver |
 Henry KingiSkin | Skin |