Gord's Brother is set in a world where monsters and humans co-exist, and follows the story of Gord and his monster brother as they run away to find a new home and search for the fabled City of Monsters.
| Actor | Role |
|---|---|
 Jack IrvineGord | Gord |
 Jacob TremblayYoung Gord | Young Gord |
| DDavid MylreaEthan | Ethan |
 Lochlyn MunroHank | Hank |
 Chelah HorsdalAmanda | Amanda |
 Michael HoganPeebles | Peebles |
 Andrea BuckoWendy | Wendy |
 Breann GraingerWanda | Wanda |
 Kwesi AmeyawDr. Paul | Dr. Paul |
| MMelanie WaldenNurse Jacqueline | Nurse Jacqueline |