 James McAvoyPatricia / Dennis / Hedwig / The Beast / Barry / Heinrich / Jade / Ian / Mary Reynolds / Norma / Jalin / Kat / B.T. / Kevin Wendell Crumb / Mr. Pritchard / Felida / Luke / Goddard / Samuel / Polly | Patricia / Dennis / Hedwig / The Beast / Barry / Heinrich / Jade / Ian / Mary Reynolds / Norma / Jalin / Kat / B.T. / Kevin Wendell Crumb / Mr. Pritchard / Felida / Luke / Goddard / Samuel / Polly |
 Bruce WillisDavid Dunn / The Overseer | David Dunn / The Overseer |
 Samuel L. JacksonElijah Price / Mr. Glass | Elijah Price / Mr. Glass |
 Sarah PaulsonDr. Ellie Staple | Dr. Ellie Staple |
 Anya Taylor-JoyCasey Cooke | Casey Cooke |
 Spencer Treat ClarkJoseph Dunn | Joseph Dunn |
 Charlayne WoodardMrs. Price | Mrs. Price |
 Luke KirbyPierce | Pierce |
 Adam David ThompsonDaryl | Daryl |
 M. Night ShyamalanJai, Security Guard | Jai, Security Guard |
 Shannon Destiny RyanCheerleading Girl | Cheerleading Girl |
 Diana SilversCheerleading Girl | Cheerleading Girl |
 Nina WisnerCheerleading Girl | Cheerleading Girl |
 Kyli ZionCheerleading Girl | Cheerleading Girl |
 Serge DidenkoRonald, Powerful Young Man | Ronald, Powerful Young Man |
 Russell PosnerT, Skinny Camera Kid | T, Skinny Camera Kid |
 Kimberly S. FairbanksAssistant Principal | Assistant Principal |
 Rosemary HowardPenelope Crumb | Penelope Crumb |
 Bryan McElroyClarence Crumb | Clarence Crumb |
 Owen VitulloYoung Kevin | Young Kevin |
| WWilliam TurnerYoung Elijah | Young Elijah |
| JJohnny Hiram JamisonThirteen Year-Old Elijah (archive footage) | Thirteen Year-Old Elijah (archive footage) |
 Leslie StefansonWoman on Train | Woman on Train |
 Marc H. GlickTrain Engineer | Train Engineer |
| BBrick MasonCarnival Barker | Carnival Barker |
 Bostin ChristopherComic Book Counter Guy | Comic Book Counter Guy |
 Ukee WashingtonNews Anchor | News Anchor |
| CColin BeckerTen Year-Old David | Ten Year-Old David |
 Brian Anthony WilsonSecurity Guard in Car | Security Guard in Car |
 Tobias SegalSurveillance Security Guard | Surveillance Security Guard |
