When single mom Callie and her two kids Trevor and Phoebe arrive in a small Oklahoma town, they begin to discover their connection to the original Ghostbusters and the secret legacy their grandfather left behind.
| Actor | Role |
|---|---|
 Mckenna GracePhoebe | Phoebe |
 Finn WolfhardTrevor | Trevor |
 Carrie CoonCallie | Callie |
 Paul RuddGrooberson | Grooberson |
 Logan KimPodcast | Podcast |
 Celeste O'ConnorLucky | Lucky |
 Bill MurrayPeter Venkman | Peter Venkman |
 Dan AykroydRay Stantz | Ray Stantz |
 Ernie HudsonWinston Zeddemore | Winston Zeddemore |
 Annie PottsJanine Melnitz | Janine Melnitz |
 Sigourney WeaverDana Barrett | Dana Barrett |
 Bob GuntonThe Ghost Farmer | The Ghost Farmer |
 J.K. SimmonsIvo Shandor | Ivo Shandor |
 Shawn SewardSkittles | Skittles |
 Billy BrykZahk | Zahk |
 Sydney Mae DíazSwayze | Swayze |
 Hannah DukeReseda | Reseda |
 Bokeem WoodbineSheriff Domingo | Sheriff Domingo |
 Paulina AlexisBunny | Bunny |
 Marlon KazadiThick Neck | Thick Neck |
| CChiara PetersenBurner Girl | Burner Girl |
 Danielle KennedyRoller Granny | Roller Granny |
 Artoun NazarethRufus | Rufus |
 Crystal RoseboroughCrystal | Crystal |
 Dušan RokvićLandlord | Landlord |
 Emma PortnerSpirit of Gozer | Spirit of Gozer |
 Stella AykroydDeputy Medjuck | Deputy Medjuck |
 Kim FairesWaitress | Waitress |
 Josh GadMuncher (voice) | Muncher (voice) |
 Shohreh AghdashlooGozer (voice) | Gozer (voice) |