 Maureen McCormickBarbara Mandrell | Barbara Mandrell |
 Dwight SchultzIrby Mandrell | Irby Mandrell |
 Greg KeanKen Dudney | Ken Dudney |
 Lisa BlountMary Mandrell | Mary Mandrell |
 Lindsey HaunBarbara (as a Teenager) | Barbara (as a Teenager) |
| JJaime DudneyIrlene Mandrell | Irlene Mandrell |
 Portia DawsonLouisa Mandrell | Louisa Mandrell |
 Jesse LittlejohnMatthew Dudney | Matthew Dudney |
 Evan Rachel WoodJaime Dudney - Age 8 | Jaime Dudney - Age 8 |
 John DoeJoe Maphis | Joe Maphis |
 Dolly PartonDolly Parton | Dolly Parton |
 Kenny RogersKenny Rogers | Kenny Rogers |
| BBarbara MandrellSelf | Self |
 Robert ClotworthyDr. Newton Louvern | Dr. Newton Louvern |
 Leonard Kelly-YoungDr. David Jones | Dr. David Jones |
| RRay ColbertBilly Sherrill | Billy Sherrill |
 Raymond SingerDr. Art Bond | Dr. Art Bond |
 Joe BaysAubrey Harwell | Aubrey Harwell |
 J.D. HintonMale Musician | Male Musician |
 Brittney Lee HarveyJaime (at Age 4) | Jaime (at Age 4) |
| JJenifer Rose OlivaresLouise | Louise |
| TTonya WattsYoung Dolly Parton | Young Dolly Parton |
| JJayson CreekProducer | Producer |
| MMichael WhiteNetwork Executive | Network Executive |
 Elizabeth GuberER Nurse | ER Nurse |
| KKen PhillipsBarbara's ER Doctor | Barbara's ER Doctor |
| DDavid PermenterAmbulance Attendant | Ambulance Attendant |
 Valentina CastellaniForeign Lady (uncredited) | Foreign Lady (uncredited) |
 Lisa HaleyYoung Barbara's Fiddler (uncredited) | Young Barbara's Fiddler (uncredited) |