 Christopher ShowermanGeorge | George |
 Julie BenzUrsula | Ursula |
 Angus T. JonesGeorge Jr. | George Jr. |
 Thomas Haden ChurchLyle Van de Groot | Lyle Van de Groot |
 Christina PicklesBeatrice Stanhope | Beatrice Stanhope |
 John CleeseAn Ape Named 'Ape' (voice) | An Ape Named 'Ape' (voice) |
 Michael Clarke DuncanMean Lion (voice) | Mean Lion (voice) |
 John KassirRocky / Armando (voice) | Rocky / Armando (voice) |
 Kevin GreutertTookie (voice) | Tookie (voice) |
 Keith ScottNarrator (voice) | Narrator (voice) |
 Kelly MiraccoBetsy | Betsy |
| KKirstie HuttonTiffany | Tiffany |
| CChelsea GibbCourtney | Courtney |
| RRichard MueckApe | Ape |
 Erika HeynatzKowalski | Kowalski |
 Marjean HoldenSally | Sally |
| LLydell M. CheshierBateke | Bateke |
 Abdoulaye N'GomKip | Kip |
 Lamont ThompsonN'Dugu | N'Dugu |
| KKerry CaseyGrouchy Gorilla | Grouchy Gorilla |
 Marco SinigagliaDopey Gorilla | Dopey Gorilla |
| SShaun MackayHappy Gorilla | Happy Gorilla |
 Kevin Michael RichardsonGrouchy Ape / Chimp (voice) | Grouchy Ape / Chimp (voice) |
 Tress MacNeilleTiger (voice) | Tiger (voice) |
 Dee Bradley BakerWater Buffalo / Little Monkey (voice) | Water Buffalo / Little Monkey (voice) |
| DDean VegasElvis Impersonator | Elvis Impersonator |
| PPaul WayneKenny Rogers Impersonator | Kenny Rogers Impersonator |
| DDaniel SeetoAncient Asian Man | Ancient Asian Man |
 Peta SergeantAttractive Woman | Attractive Woman |
| JJeff McTaggartHelicopter Pilot | Helicopter Pilot |
