Guathamante Radham revolves around Gauthaman and his journey of getting a driving license and, for the first time in the family, a car of his own. The relationship he builds with the car and the fortunes brought by the car.
| Actor | Role |
|---|---|
 Neeraj MadhavGauthaman | Gauthaman |
 Basil JosephVenkidi | Venkidi |
 Renji PanickerRamachandran | Ramachandran |
 Devi AjithSreelekha | Sreelekha |
 Punya Elizabeth BoseKalyani | Kalyani |
 Biju SopanamShibu Aashan | Shibu Aashan |
 Valsala MenonMuthassi | Muthassi |
 Hareesh PerumannaBasheer | Basheer |
 Vishnu GovindanSambath Annan | Sambath Annan |
 Prajod KalabhavanDundhu Francis (SI) | Dundhu Francis (SI) |
 Hareesh PenganAnirudhan | Anirudhan |
 Anand MenenNimmy's Boy Friend | Nimmy's Boy Friend |
| NNadiyaNimmy | Nimmy |
 Joemon JyothirGuy In Accident Scene | Guy In Accident Scene |
 AchuthanandanHotel Owner | Hotel Owner |
 Vasudev Sajeesh MararYoung Gauthaman(10 years) | Young Gauthaman(10 years) |
| SSuryadev Sajeesh MararYoung Gauthaman(6 years) | Young Gauthaman(6 years) |