Everyone's favorite lazy, lasagna loving, Monday hating orange tabby leaves his exciting star of a popular comic strip world for the real one. But as the novelty wears thin, Garfield begins looking for a way back before his strip is permanently cancelled.
| Actor | Role |
|---|---|
 Frank WelkerGarfield / Keith / Prop Boy / Additional Voices (voice) | Garfield / Keith / Prop Boy / Additional Voices (voice) |
 Rajia BaroudiSheila / Concertina Girl (voice) | Sheila / Concertina Girl (voice) |
 Gregg BergerOdie / Shecky / Hale (voice) | Odie / Shecky / Hale (voice) |
 Greg EaglesEli (voice) | Eli (voice) |
 Jason MarsdenNermal (voice) | Nermal (voice) |
 Audrey WasilewskiArlene / Zelda / Betty / Ashley (voice) | Arlene / Zelda / Betty / Ashley (voice) |
 Pat FraleyDelivery Gnome / Sid (voice) | Delivery Gnome / Sid (voice) |
 Wally WingertJon Arbuckle / Mike (voice) | Jon Arbuckle / Mike (voice) |
 Neil RossWally / Charles (voice) | Wally / Charles (voice) |
 Jennifer DarlingBonita / Mother / Rusty / Bobby (voice) | Bonita / Mother / Rusty / Bobby (voice) |
 David MichieTape Holder (voice) | Tape Holder (voice) |
 Harold PerrineauHusband (voice) | Husband (voice) |
 Stephen StantonRandy / Father (voice) | Randy / Father (voice) |
 Fred TatascioreBilly / Waldo / Eric (voice) | Billy / Waldo / Eric (voice) |