As political cartoonist Duffy and his bride Meg fail to conceive, he and sorority girl Daphne succeed.
| Actor | Role |
|---|---|
 Gene WilderDuffy Bergman | Duffy Bergman |
 Christine LahtiMeg | Meg |
 Mary Stuart MastersonDaphne | Daphne |
 Robert ProskyE. T. | E. T. |
 Stephen TobolowskyHugo | Hugo |
 Anne JacksonAdele | Adele |
 Susan RuttanClaire | Claire |
 Jean De BaerVivian | Vivian |
 David MarguliesDr. Benjamin | Dr. Benjamin |
 Tara ShannonRedhead | Redhead |
 Freda Foh ShenNurse | Nurse |
 Wendie MalickNurse Nancy | Nurse Nancy |
 Robert Hy GormanRoger | Roger |
| SScott GroffJake | Jake |
 Ramy ZadaEllis Hayden | Ellis Hayden |
 Lorenzo CaccialanzaSotto Voce Maitre d' | Sotto Voce Maitre d' |
 Justin RossWaiter | Waiter |
 Paul CollinsBill Hatcher | Bill Hatcher |
 Andrew Hill NewmanJerry | Jerry |
| CCourtney BarillaAlexandra | Alexandra |
| KKevin ShawWaiter | Waiter |