FROM OTHER WORLDS is a sci-fi comedy about a depressed Brooklyn housewife who sleepwalks through her life until she encounters an alien force in her backyard. With the help of a fellow contactee, an African immigrant, she is determined to solve the mystery of her otherworldly experiences. Along the way, she finds romance, saves the planet and finds new meaning in her life.
| Actor | Role |
|---|---|
 Cara BuonoJoanne | Joanne |
 Robert Downey Sr.Baker | Baker |
| JJonah MeyersonHenry | Henry |
 Quinn ShephardLinda | Linda |
 David LansburyBrian | Brian |
| RRichard M. DavidsonDoctor | Doctor |
 Lori Tan ChinnMrs. Kim | Mrs. Kim |
 Laura EstermanPsychiatrist | Psychiatrist |
| DDavid SmilowScience Reporter | Science Reporter |
| MMichael ClintonFarmer | Farmer |
 Isaach de BankoléAbraham | Abraham |
 Robert PetersSteve | Steve |
 Melissa LeoMiriam | Miriam |
 Paul LazarLarry | Larry |
 Helen HanftShirley | Shirley |
 Jimmy Gary Jr.Sam | Sam |
 Rony ClantonFrank | Frank |
 Sharon WilkinsJill | Jill |
 Joel de la FuenteAlien | Alien |
 Marcia Jean KurtzBrian's Mom | Brian's Mom |
| LLarry BlockBrian's Dad | Brian's Dad |
 Jay OakersonBig Lab Assistant | Big Lab Assistant |
 Gregory KorostishevskySmall Lab Assistant | Small Lab Assistant |
 Kristen SchaalInformation Librarian | Information Librarian |
 Peter BartlettCurator | Curator |
 Susham BediVegetarian | Vegetarian |
 Ed WheelerGuard | Guard |
 Joseph McKennaConfessor | Confessor |
| LLori BravermanWoman Gambler | Woman Gambler |
| AAlberto VasquezJerry | Jerry |