 Owen WilsonReggie (voice) | Reggie (voice) |
 Woody HarrelsonJake (voice) | Jake (voice) |
 Amy PoehlerJenny (voice) | Jenny (voice) |
 George TakeiS.T.E.V.E. (voice) | S.T.E.V.E. (voice) |
 Colm MeaneyMyles Standish (voice) | Myles Standish (voice) |
 Keith DavidChief Broadbeak (Voice) | Chief Broadbeak (Voice) |
 Dan FoglerGovernor William Bradford (voice) | Governor William Bradford (voice) |
 Jimmy HaywardRanger / Leatherbeak / President / Hazmats (voice) | Ranger / Leatherbeak / President / Hazmats (voice) |
| JJeff BiancalanaGeneral Sagan / Hazmats (voice) | General Sagan / Hazmats (voice) |
 Danny CareyDanny (voice) | Danny (voice) |
 Carlos PonceNarrator / Alejandro (voice) | Narrator / Alejandro (voice) |
 Robert BeltranChief Massasoit (voice) | Chief Massasoit (voice) |
 Lesley NicolFemale Pilgrim (voice) | Female Pilgrim (voice) |
 Kaitlyn MaherPresident's Daughter (voice) | President's Daughter (voice) |
 Carlos AlazraquiAmos (voice) | Amos (voice) |
 Josh LawsonGus (Voice) | Gus (Voice) |
| JJason FinazzoChrononaut One (voice) | Chrononaut One (voice) |
 Scott MosierPizza Dude (voice) | Pizza Dude (voice) |
 Lauren BowlesJake's Mother (voice) | Jake's Mother (voice) |
 Dwight HowardCold Turkey (Voice) | Cold Turkey (Voice) |
 Vincente DiSanti(voice) | (voice) |
 Jeffrey Fierson(voice) | (voice) |
 David S. Lee(voice) | (voice) |
| RRik Michul(voice) | (voice) |
 Alina Phelan(voice) | (voice) |
 William Morgan Sheppard(voice) | (voice) |
