Lonely guy Fred Stoller is thrilled when his good buddy, Vinnie D'Angelo, the world's happiest agoraphobic and fattest vegetarian, comes to live with him, until Vinnie also proves to be the world's most maddening roommate.
| Actor | Role |
|---|---|
 Fred WillardMovie Star | Movie Star |
 Justin RoilandPizza Delivery Guy | Pizza Delivery Guy |
 Fred StollerFred | Fred |
 Richard Steven HorvitzBook Store Autoraph Hound | Book Store Autoraph Hound |
 Craig Lamar TraylorBook Store Customer | Book Store Customer |
 John AsherMr. Basin | Mr. Basin |
 Michael BenyaerBook Store Customer | Book Store Customer |
| SSarah RushTheresa | Theresa |
 Hamilton MitchellInterviewer | Interviewer |
 Jack AxelrodLeo | Leo |
 Lee RehermanAdam Clark | Adam Clark |
 Tonita CastroLatina Neighbor | Latina Neighbor |
 Robyn Von ArxDancing Nun | Dancing Nun |
 Angelo TsarouchasVinnie DeAngelo | Vinnie DeAngelo |
 Hiram KastenApartment Manager #1 | Apartment Manager #1 |
 Ellie KnausDarlene | Darlene |
 Richard TannerBarry Carlson | Barry Carlson |
 Scott ChernoffLuther | Luther |