Years after Tess and Anna endured an identity crisis, Anna now has a daughter of her own and a soon-to-be stepdaughter. As they navigate the myriad challenges that come when two families merge, Tess and Anna discover lightning might indeed strike twice.
| Actor | Role |
|---|---|
 Lindsay LohanAnna Coleman | Anna Coleman |
 Jamie Lee CurtisTess Coleman | Tess Coleman |
 Julia ButtersHarper Coleman | Harper Coleman |
 Sophia HammonsLily Reyes | Lily Reyes |
 Manny JacintoEric Reyes | Eric Reyes |
 Mark HarmonRyan | Ryan |
 Chad Michael MurrayJake | Jake |
 Vanessa BayerMadame Jen | Madame Jen |
 Maitreyi RamakrishnanElla | Ella |
 Lucille SoongGrandma Chiang | Grandma Chiang |
 Rosalind ChaoMama P | Mama P |
 Stephen TobolowskyMr. Elton Bates | Mr. Elton Bates |
 Christina Vidal MitchellMaddie | Maddie |
 Haley HudsonPeg | Peg |
 X MayoPrincipal Waldman | Principal Waldman |
| JJordan E. CooperJett | Jett |
 June Diane RaphaelVeronica | Veronica |
 Mary SohnVivian | Vivian |
| SSantina MuhaJudy (INS Agent) | Judy (INS Agent) |
 Aryan SimhadriJai | Jai |
 George WallaceGeorge Wallace | George Wallace |
 Sherry ColaSherry Cola | Sherry Cola |
 Kylah DavilaAthena | Athena |
| NNell MurphyBeta Girl | Beta Girl |
 Noen PerezJulian | Julian |
 Ryan MalgariniHarry | Harry |
 Valentina GarciaMs. Kathleen | Ms. Kathleen |
 Jimmy BellingerCayden | Cayden |
 Ahmed BharoochaStarbucks Employee | Starbucks Employee |
 David MirandaRizz Kid | Rizz Kid |