A vain actor, his best friend, and an activist end up at a mutant freak farm run by a weirdo scientist.
| Actor | Role |
|---|---|
 Alex WinterRicky Coogan | Ricky Coogan |
 Michael StoyanovErnie | Ernie |
 William SadlerDick Brian | Dick Brian |
 Megan WardJulie | Julie |
 Mr. TThe Bearded Lady | The Bearded Lady |
 Brooke ShieldsSkye Daley | Skye Daley |
 Alex ZuckermanStuey Gluck | Stuey Gluck |
 Ray BakerBill Blazer | Bill Blazer |
 Morgan FairchildStewardess | Stewardess |
 Patti TippoRosie the Pinhead | Rosie the Pinhead |
 Lee ArenbergThe Eternal Flame | The Eternal Flame |
 John HawkesCowboy | Cowboy |
 Derek McGrathWorm | Worm |
 Jeff KahnNosey | Nosey |
 Randy QuaidElijah C. Skuggs | Elijah C. Skuggs |
| EEduardo RicardGeorge Ramirez | George Ramirez |
| HHenry CarboGeorge Ramirez | George Ramirez |
 Deep RoyGeorge Ramirez | George Ramirez |
 Mihaly 'Michu' MeszarosGeorge Ramirez | George Ramirez |
 Brian BrophyKevin | Kevin |
 Jaime CardricheToad | Toad |
| NNicholas CohnBob Vila Look-A-Like | Bob Vila Look-A-Like |
| KKaryn MalchusSockhead | Sockhead |
| TTim BurnsFrogman | Frogman |
 Bobcat GoldthwaitSockhead | Sockhead |
 Don StarkEditor | Editor |
 Arturo GilClown | Clown |
 Tom SternMan / Milkman | Man / Milkman |
 Gibby HaynesCheese Wart | Cheese Wart |
| PPamela MantNun | Nun |