From Boris Karloff to Mel Brooks - Frankenstein has fired the imagination of generations of artists who have created their own interpretation of this Gothic masterpiece. Frankenstein: A Modern Myth looks at some of these depictions, including Danny Boyle's sell-out hit at the National Theatre. The film has exclusive access to rehearsals and interviews with Benedict Cumberbatch and Jonny Lee Miller - who alternate the roles of Victor Frankenstein and the Creature - and with Danny Boyle. It also features cult film director John Waters: "I'm sympathetic to monsters, and this was the first one I came across as a child".
| Actor | Role |
|---|---|
 David BradleySelf - Narrator (voice) | Self - Narrator (voice) |
 Daniel IngsReadings (voice) | Readings (voice) |
| SSarah MowatReadings (voice) | Readings (voice) |
 Danny BoyleSelf | Self |
 Benedict CumberbatchSelf / Frankenstein / The Monster | Self / Frankenstein / The Monster |
 John WatersSelf - Director | Self - Director |
 Jonny Lee MillerSelf / Frankenstein / The Monster | Self / Frankenstein / The Monster |
| GGwen AdsheadSelf - Chief Forensic Psychotherapist, Broadmoor Hospital (as Dr. Gwen Adshead) | Self - Chief Forensic Psychotherapist, Broadmoor Hospital (as Dr. Gwen Adshead) |
| PPhilip BallSelf - Historian of Science | Self - Historian of Science |
| NNick DearSelf - Playwright | Self - Playwright |
| DDaisy HaySelf - Mary Shelley Biographer | Self - Mary Shelley Biographer |
| SStephen HebronSelf - Bodleian Library, Oxford | Self - Bodleian Library, Oxford |
| PPhilip HoareSelf - Writer | Self - Writer |
| MMiranda SeymourSelf - Mary Shelley Biographer | Self - Mary Shelley Biographer |
| HHelen WallaceSelf - Genetics Ethicist | Self - Genetics Ethicist |