An investigation into a serial killer leads two detectives to discover that Dr. Frankenstein and his creature are still alive after two centuries of genetic experiments.
| Actor | Role |
|---|---|
 Parker PoseyDetective Carson O'Conner | Detective Carson O'Conner |
 Vincent PerezDeucalion | Deucalion |
 Thomas KretschmannVictor Helios | Victor Helios |
 Adam GoldbergDetec. Michael Sloane | Detec. Michael Sloane |
 Ivana MiličevićErika Helios | Erika Helios |
 Michael MadsenDetec. Harker | Detec. Harker |
| DDeborah DukeAngelique | Angelique |
 Ann MahoneyJenna | Jenna |
 Deneen TylerKathleen Burke | Kathleen Burke |
 Brett RiceDetec. Frye | Detec. Frye |
 Stocker FontelieuPatrick | Patrick |
 Maureen BrennanVickey | Vickey |
| BBilly LouviereJack Rogers | Jack Rogers |
| WWill SchierhornAnthony O'Connor | Anthony O'Connor |
 Tom NowickiWatkins | Watkins |
 David JensenFullbright | Fullbright |
 Sandra DorseyNancy Whistler | Nancy Whistler |
| LLauren SwinneyChristine | Christine |
| TThirl HastonSailor | Sailor |
| AAnne EwenSandra | Sandra |