 Charlie SheenDex Dogtective (voice) | Dex Dogtective (voice) |
 Hilary DuffSunshine Goodness (voice) | Sunshine Goodness (voice) |
 Eva LongoriaLady X (voice) | Lady X (voice) |
 Wayne BradyDaredevil Dan (voice) | Daredevil Dan (voice) |
 Christopher LloydMr. Clipboard (voice) | Mr. Clipboard (voice) |
 Chris KattanPolar Penguin (voice) | Polar Penguin (voice) |
 Larry MillerVlad Chocool (voice) | Vlad Chocool (voice) |
 Ed AsnerMr. Leonard (voice) | Mr. Leonard (voice) |
 Jerry StillerGeneral X (voice) | General X (voice) |
 Martin KlebbaGeneral X / Kaptain Krispy (voice) | General X / Kaptain Krispy (voice) |
 Christine BaranskiHedda Shopper (voice) | Hedda Shopper (voice) |
 Lawrence KasanoffCheasel T. Weasel (voice) | Cheasel T. Weasel (voice) |
 Harvey FiersteinFat Cat Burglar (voice) | Fat Cat Burglar (voice) |
 Cloris LeachmanBrand X Lunch Lady (voice) | Brand X Lunch Lady (voice) |
 Haylie DuffSweet Cakes (voice) | Sweet Cakes (voice) |
 Shelley MorrisonLola Frutola (voice) | Lola Frutola (voice) |
 Edie McClurgMrs. Butterworth (voice) | Mrs. Butterworth (voice) |
| GGeorge JohnsenKaptain Krispy / Hairless Hamster Henchman (voice) | Kaptain Krispy / Hairless Hamster Henchman (voice) |
 Greg EllisHairy Hold (voice) | Hairy Hold (voice) |
 James Arnold TaylorDr. Si Nustrix / Additonal Voices (voice) | Dr. Si Nustrix / Additonal Voices (voice) |
 Robert CostanzoMaximilius Moose (voice) (as Bobby Constanza) | Maximilius Moose (voice) (as Bobby Constanza) |
 Jeff BennettLieutenant X/Additional Voices (voice) | Lieutenant X/Additional Voices (voice) |
 Stephen StantonMr. Clean / Lord Flushington / Additional Voices (voice) | Mr. Clean / Lord Flushington / Additional Voices (voice) |
 Jeff BergmanCharlie Tuna (voice) | Charlie Tuna (voice) |
| KKaren Gallo MessoreBlue (voice) | Blue (voice) |
 Sean Catherine DerekToddler's Mom (voice) | Toddler's Mom (voice) |
 Enn ReitelKung Tofu / Fracois Fromage (voice) | Kung Tofu / Fracois Fromage (voice) |
 Daniel FranzeseTwinkleton (voice) | Twinkleton (voice) |
 Eliza SchneiderSweet Older Lady (voice) | Sweet Older Lady (voice) |
| JJason OrtenbergIke Kid #1 (voice) | Ike Kid #1 (voice) |
