 Tim CurryYegor (voice) | Yegor (voice) |
 Robert PatrickLouie (voice) | Louie (voice) |
 Kelly RipaNat's Mom (voice) | Nat's Mom (voice) |
 Trevor GagnonNat (voice) | Nat (voice) |
 Philip BoldenI.Q. (voice) | I.Q. (voice) |
 Nicollette SheridanNadia (voice) | Nadia (voice) |
 Ed Begley Jr.Poopchev (voice) | Poopchev (voice) |
 David GoreScooter (voice) | Scooter (voice) |
 Christopher LloydAmos (voice) | Amos (voice) |
 Adrienne BarbeauScooters Mom (voice) | Scooters Mom (voice) |
 Buzz AldrinHimself | Himself |
| EEddie FriersonCommander Aldrin | Commander Aldrin |
 David CowgillCommander Collins | Commander Collins |
| SSteven KramerLeonide | Leonide |
| SSophie SimpsonKatie (voice) | Katie (voice) |
| SSandy SimpsonCommander Armstrong (voice) | Commander Armstrong (voice) |
 Phil ProctorSenior Official (voice) | Senior Official (voice) |
 Lloyd SherrMission Control 1969 (voice) | Mission Control 1969 (voice) |
 Nicholas GuestFly Buddy #1 (voice) | Fly Buddy #1 (voice) |
 Archie HahnFly Buddy #2 | Fly Buddy #2 |
 Lynnanne ZagerFly at Launch (voice) | Fly at Launch (voice) |
 Scott MenvilleButch (voice) | Butch (voice) |
 Michael McConnohieAmerican Newscaster (voice) | American Newscaster (voice) |
| DDoug StoneRussian Newscaster (voice) | Russian Newscaster (voice) |
 Jessica Gee-GeorgeMaggot #1 (voice) | Maggot #1 (voice) |
 Mona MarshallMaggot #2 (voice) | Maggot #2 (voice) |
 Barbara GoodsonMaggot #3 (voice) | Maggot #3 (voice) |
 Gregg BergerPale Russian Fly (voice) | Pale Russian Fly (voice) |
 Grant GeorgePale Russian Fly (voice) | Pale Russian Fly (voice) |
| DDean WeinAdditional Voices (voice) | Additional Voices (voice) |
