Charlie Gordon is mentally handicapped and all he wants in life is to be a genius. When he gets picked for experimental surgery it looks like his dream may finally come true. But the surgery has side effects that could could kill Charlie. Can Charlie survive being just plain old "Charlie Gordon" and will his newfound romance survive this test of character?
| Actor | Role |
|---|---|
 Matthew ModineCharlie Gordon | Charlie Gordon |
 Kelli WilliamsAlice Kinian | Alice Kinian |
 Ron RifkinDr. Jonah Strauss | Dr. Jonah Strauss |
 Bonnie BedeliaRose | Rose |
 Gloria SladeFaye | Faye |
 Cliff SaundersMike | Mike |
 Kathryn KirkpatrickBernice | Bernice |
| DDavid McFarlaneLester | Lester |
| RRonit CohenFrancine | Francine |
 Carson DurvenOliver | Oliver |
| HHayley LochnerHarriet | Harriet |
 Cameron BowenYoung Charlie | Young Charlie |
| AAndrew DinnerFirst Teen | First Teen |
| LLiam TitcombSecond Teen | Second Teen |
 Ron KennellBakery Worker | Bakery Worker |
| VVince GuerrieroBartender | Bartender |
 Mo KelsoFemale Neighbor | Female Neighbor |
| BBilly KhouryMale Neighbor | Male Neighbor |