 John WayneDuke Fergus | Duke Fergus |
 Ann DvorakAnn 'Flaxen' Tarry | Ann 'Flaxen' Tarry |
 Joseph SchildkrautBoss Tito Morell | Boss Tito Morell |
 William FrawleyWolf Wylie | Wolf Wylie |
 Virginia GreyRita Dane | Rita Dane |
 Russell HicksCyrus Danver, Owner San Francisco Star | Cyrus Danver, Owner San Francisco Star |
 Jack NortonByline Conners, Reporter San Francisco Star | Byline Conners, Reporter San Francisco Star |
 Paul FixCalico Jim | Calico Jim |
| MManart KippenDr. Gorman | Dr. Gorman |
| EEve LynneMartha, Morell's Secretary | Martha, Morell's Secretary |
 Marc LawrenceJoe Disko, Gambler | Joe Disko, Gambler |
 Butterfly McQueenBeulah, Flaxen's Maid | Beulah, Flaxen's Maid |
 Rex LeaseCollingswood | Collingswood |
 Hank BellHank | Hank |
| AAl MurphyHorseshoe Brown | Horseshoe Brown |
 Eddie AcuffSmokey, the Train Engineer (uncredited) | Smokey, the Train Engineer (uncredited) |
 Gino CorradoWaiter (uncredited) | Waiter (uncredited) |
 Kenne DuncanGambler (uncredited) | Gambler (uncredited) |
 Bud GearyHenchman (uncredited) | Henchman (uncredited) |
 Frank HagneyMorell Henchman (uncredited) | Morell Henchman (uncredited) |
| WWilliam Hoehne Jr.Blond haired boy delivering beer (uncredited) | Blond haired boy delivering beer (uncredited) |
 Adele MaraMarie (uncredited) | Marie (uncredited) |
 Jack MulhallGambler (uncredited) | Gambler (uncredited) |
| DDoc AdamsBarfly | Barfly |
| MMelva AnsteadDancehall Girl | Dancehall Girl |
| WWalter BaconBarfly | Barfly |
| FFrank BalderramaBarfly | Barfly |
| JJohn BartonBarfly | Barfly |
| EEdward BibyBill McGale | Bill McGale |
| GGeorge BoyceSpecialty Dancer | Specialty Dancer |
