Cécile, Annette, Yvonne, Émilie and Marie, the Dionne Quintuplets, turn five years old and have a private birthday party in their garden. Other than the five little French-Canadian princesses-of-the-world, the attendees at the party for the sheltered sisters are their doctor-and-mentor Roy Dafoe; a priest and two nurses; radio's "Town Crier" Alexander Woollcott; and RKO-Newsreel cameraman Harry Smith.
| Actor | Role |
|---|---|
 Alexander WoollcottCommentator | Commentator |
| YYvonne DionneHerself, a Dionne Quintuplet | Herself, a Dionne Quintuplet |
| AAnnette DionneHerself, a Dionne Quintuplet | Herself, a Dionne Quintuplet |
| CCécile DionneHerself, a Dionne Quintuplet | Herself, a Dionne Quintuplet |
| ÉÉmilie DionneHerself, a Dionne Quintuplet | Herself, a Dionne Quintuplet |
| MMarie DionneHerself, a Dionne Quintuplet | Herself, a Dionne Quintuplet |
| AAllan Roy DafoeHimself, the Dionne Quintuplets' Doctor | Himself, the Dionne Quintuplets' Doctor |