Rival reporters compete to sign the Wyatt Quintuplets to be guests on their radio shows.
| Actor | Role |
|---|---|
| YYvonne DionneYvonne, a Wyatt Quintuplet | Yvonne, a Wyatt Quintuplet |
| AAnnette DionneAnnette, a Wyatt Quintuplet | Annette, a Wyatt Quintuplet |
| CCécile DionneCécile, a Wyatt Quintuplet | Cécile, a Wyatt Quintuplet |
| ÉÉmilie DionneÉmilie, a Wyatt Quintuplet | Émilie, a Wyatt Quintuplet |
| MMarie DionneMarie, a Wyatt Quintuplet | Marie, a Wyatt Quintuplet |
 Jean HersholtDr. John Luke | Dr. John Luke |
 Claire TrevorChristine Nelson | Christine Nelson |
 Cesar RomeroDuke Lester | Duke Lester |
 Slim SummervilleConstable Jim Ogden | Constable Jim Ogden |
 Henry WilcoxonDr. Scott Williams | Dr. Scott Williams |
 Inez CourtneyLibby Long | Libby Long |
 John QualenAsa Wyatt | Asa Wyatt |
 Jane DarwellNurse Waldron | Nurse Waldron |
 Pauline MooreElinor Kingsley | Elinor Kingsley |
 Johnny RussellDickie Post | Dickie Post |
 Andrew TombesDr. Bruno | Dr. Bruno |
 Spencer ChartersRev. Matthew Brand | Rev. Matthew Brand |