 River PhoenixSelf (archive footage) | Self (archive footage) |
 Joaquin PhoenixSelf (voice) (archive footage) | Self (voice) (archive footage) |
 Danny WallaceNarrator | Narrator |
| DDarryl DoughertyRiver Phoenix | River Phoenix |
| MMichael CooperJoaquin Phoenix | Joaquin Phoenix |
| JJennifer DonisonRain Phoenix | Rain Phoenix |
| MMatthew EbertSelf | Self |
 Dick RudeSelf | Self |
| SSteve WoodSelf | Self |
| DDirk DrakeSelf | Self |
| SSasa RaphaelSelf - Bassist, Aleka's Attic | Self - Bassist, Aleka's Attic |
| PPleasant GehmanSelf - Author & Journalist | Self - Author & Journalist |
| MMike LeeSelf - Detective Sergeant, LAPD | Self - Detective Sergeant, LAPD |
| DDan AndersonSelf - Toxicologist | Self - Toxicologist |
| VVinnie ScottSelf - Paramedic | Self - Paramedic |
| AAnthony DunnFlea | Flea |
| JJulia KulfulSamantha Mathis | Samantha Mathis |
| NNick AbrahamDick Rude | Dick Rude |
| MMia VincentAbby Rude | Abby Rude |
| IIan McInnesGeorge Sluizer | George Sluizer |
| TTania KolarJudy Davis | Judy Davis |
| RRobert KeeleEd Lachman | Ed Lachman |
| TTrevor BenhamJohn Frusciante | John Frusciante |
| RRobert CareltonBouncer | Bouncer |
| BBen BessongPharmacist | Pharmacist |
 FleaSelf (archive footage) | Self (archive footage) |
 George SluizerSelf - Director, Dark Blood | Self - Director, Dark Blood |
 Edward LachmanSelf - Cinematographer, Dark Blood | Self - Cinematographer, Dark Blood |
 William RichertSelf | Self |