 Matt FurieSelf - Artist, Creator of Pepe the Frog | Self - Artist, Creator of Pepe the Frog |
| AAiyana UdesenSelf - Artist, Matt's Partner | Self - Artist, Matt's Partner |
| CChris SullivanSelf - Matt & Aiyana's Housemate | Self - Matt & Aiyana's Housemate |
| JJohnny RyanSelf - Typical Cartoonist | Self - Typical Cartoonist |
 Lisa HanawaltSelf - Artist & Writer | Self - Artist & Writer |
 Emily HellerSelf - Comedian & TV Writer | Self - Comedian & TV Writer |
| SSusan BlackmoreSelf - Psychologist & Memetist | Self - Psychologist & Memetist |
| DDale BeranSelf - Artist & Writer | Self - Artist & Writer |
| MMillsSelf - 4channer | Self - 4channer |
| PPeder RiisSelf - Cartoonist | Self - Cartoonist |
| AAleks KrotoskiSelf - Psychologist & Journalist | Self - Psychologist & Journalist |
| BBrian McMullenSelf - Editor & Art Director | Self - Editor & Art Director |
| JJoel FinkelsteinSelf - Director, Network Contagion Research Institute | Self - Director, Network Contagion Research Institute |
| AAaron SankinSelf - Journalist | Self - Journalist |
| MMatt BraynardSelf - Executive Director, Look Ahead America | Self - Executive Director, Look Ahead America |
| JJohn Michael GreerSelf - Occultist & Scholar | Self - Occultist & Scholar |
| SSkinnerSelf - Artist | Self - Artist |
| AAdam SerwerSelf - Staff Writer, The Atlantic | Self - Staff Writer, The Atlantic |
| RRachael FinleySelf | Self |
| HHampton BoyerSelf - Artist & Curator | Self - Artist & Curator |
| KKevin Sukho LeeSelf - Artist | Self - Artist |
 Arthur JonesSelf | Self |
| PPeter KellSelf - Crypto Currency Trader | Self - Crypto Currency Trader |
| JJeremy BlackburnSelf - Computer Scientist | Self - Computer Scientist |
| LLouis TomprosSelf - Copyright Attorney, WilmerHale | Self - Copyright Attorney, WilmerHale |
| SStephanie LinSelf - Copyright Attorney, WilmerHale | Self - Copyright Attorney, WilmerHale |
| OOren SegalSelf - Director, Center on Extremism, Anti-Defamation League | Self - Director, Center on Extremism, Anti-Defamation League |
 Alex E. JonesSelf - Host, InfoWars (archive footage) | Self - Host, InfoWars (archive footage) |
 Donald TrumpSelf (archive footage) | Self (archive footage) |
 Hillary ClintonSelf (archive footage) | Self (archive footage) |
