 David McCulloughNarrator | Narrator |
 Franklin D. RooseveltSelf (archive footage) | Self (archive footage) |
 Eleanor RooseveltSelf (archive footage) | Self (archive footage) |
 James RooseveltSelf (archive footage) | Self (archive footage) |
 Geoffrey C. WardSelf — Biographer | Self — Biographer |
| CCurtis RooseveltSelf — Grandson | Self — Grandson |
 Doris Kearns GoodwinSelf — Biographer | Self — Biographer |
 Blanche Wiesen CookSelf — Eleanor Roosevelt Biographer | Self — Eleanor Roosevelt Biographer |
| BBronson ChanlerSelf — Hudson Valley Neighbor | Self — Hudson Valley Neighbor |
| EEdna GurewitschSelf — Roosevelt Family Friend | Self — Roosevelt Family Friend |
| EEleanor Roosevelt SeagravesSelf — Granddaughter | Self — Granddaughter |
| GGrenville ClarkSelf (archive footage) | Self (archive footage) |
 James M. CoxSelf (archive footage) | Self (archive footage) |
| HHugh GallagherSelf — Biographer | Self — Biographer |
| EElmer LoftinSelf — Warm Springs Resident | Self — Warm Springs Resident |
| RRobert Fulton CopelandSelf — Warm Springs Resident | Self — Warm Springs Resident |
| HH. Stuart RaperSelf — Medical Director, Warm Springs Foundation | Self — Medical Director, Warm Springs Foundation |
| JJanice Howe RaperSelf — Physical Therapist | Self — Physical Therapist |
| BBen C. FowlerSelf — Warm Springs Resident | Self — Warm Springs Resident |
| AAlice ConverseSelf — Physical Therapist | Self — Physical Therapist |
| DDavid GinsburgSelf — FDR Administration | Self — FDR Administration |
| AAlonzo FieldsSelf — White House Butler | Self — White House Butler |
 Herbert HooverSelf (archive footage) | Self (archive footage) |
 Thomas J. WalshSelf (archive footage) | Self (archive footage) |
 John Nance GarnerSelf (archive footage) | Self (archive footage) |
| EEli GinzbergSelf — FDR Administration | Self — FDR Administration |
| WWilliam LeuchtenburgSelf — Historian | Self — Historian |
| CChalmers RobertsSelf — Journalist | Self — Journalist |
 Lou Henry HooverSelf (archive footage) | Self (archive footage) |
| RRobert R. NathanSelf — FDR Administration | Self — FDR Administration |
