 George ClooneyMr. Fox (voice) | Mr. Fox (voice) |
 Meryl StreepMrs. Fox (voice) | Mrs. Fox (voice) |
 Jason SchwartzmanAsh Fox (voice) | Ash Fox (voice) |
 Eric Chase AndersonKristofferson Silverfox (voice) | Kristofferson Silverfox (voice) |
 Wallace WolodarskyKylie (voice) | Kylie (voice) |
 Willem DafoeRat (voice) | Rat (voice) |
 Michael GambonFranklin Bean (voice) | Franklin Bean (voice) |
 Robin HurlstoneWalter Boggis (voice) | Walter Boggis (voice) |
 Hugo GuinnessNathan Bunce (voice) | Nathan Bunce (voice) |
 Bill MurrayClive Badger (voice) | Clive Badger (voice) |
 Helen McCroryMrs. Bean (voice) | Mrs. Bean (voice) |
 Wes AndersonStan Weasel (voice) | Stan Weasel (voice) |
 Jarvis CockerPetey (voice) | Petey (voice) |
 Owen WilsonCoach Skip (voice) | Coach Skip (voice) |
 Juman MaloufAgnes (voice) | Agnes (voice) |
 Karen DuffyLinda Otter (voice) | Linda Otter (voice) |
 Roman CoppolaSquirrel Contractor (voice) | Squirrel Contractor (voice) |
 Jeremy DawsonBeaver's Son (voice) | Beaver's Son (voice) |
 Garth JenningsBean's Son (voice) | Bean's Son (voice) |
 Brian CoxAction 12 Reporter (voice) | Action 12 Reporter (voice) |
 Tristan OliverExplosives Man (voice) | Explosives Man (voice) |
| JJames HamiltonMole (voice) | Mole (voice) |
 Steven M. RalesBeaver (voice) | Beaver (voice) |
| RRob HersovPilot (voice) | Pilot (voice) |
 Jennifer FurchesDr. Badger (voice) | Dr. Badger (voice) |
 Mario BataliRabbit (voice) | Rabbit (voice) |
 Allison AbbateRabbit's Ex-Girlfriend (voice) | Rabbit's Ex-Girlfriend (voice) |
| MMolly CooperRabbit Girl (voice) | Rabbit Girl (voice) |
 Adrien BrodyField Mouse (voice) | Field Mouse (voice) |
| MMartin BallardFire Chief (voice) | Fire Chief (voice) |
