The film follows four inter-connecting stories revolving around love, drugs and poverty in Philadelphia
| Actor | Role |
|---|---|
 Rosario DawsonBabo's Mom | Babo's Mom |
 Paul DanoRocco | Rocco |
 Jermaine CrawfordTony | Tony |
| RRebecca ComerfordKelly | Kelly |
| MMartin CepedaDemitri | Demitri |
 Francisco BurgosBabo | Babo |
 Naomie HarrisJill | Jill |
 Frankie ShawMichelle | Michelle |
 Zoe Lister-JonesJenn | Jenn |
 Lou Taylor PucciJacob | Jacob |
 Mark WebberPicket Crowd Member | Picket Crowd Member |
 EvangelineYoung Woman | Young Woman |
 Joe HansardBloody Towel Man | Bloody Towel Man |