 Jake T. AustinYankee Irving (voice) | Yankee Irving (voice) |
 Rob ReinerScrewie (voice) | Screwie (voice) |
 William H. MacyLefty Maginnis (voice) | Lefty Maginnis (voice) |
 Mandy PatinkinStanley Irving (voice) | Stanley Irving (voice) |
 Richard KindHobo Andy / Maitre D' (voice) | Hobo Andy / Maitre D' (voice) |
 Robert WagnerMr. Robinson (voice) | Mr. Robinson (voice) |
 Raven-SymonéMarti Brewster (voice) | Marti Brewster (voice) |
 Whoopi GoldbergDarlin' (voice) | Darlin' (voice) |
 Brian DennehyBabe Ruth (voice) | Babe Ruth (voice) |
| RRitchie AllenOfficer Bryant (voice) | Officer Bryant (voice) |
 Cherise BootheRosetta Brewster (voice) | Rosetta Brewster (voice) |
| RRalph CoppolaSandlot Kid #2 (voice) | Sandlot Kid #2 (voice) |
| JJesse BronsteinSandlot Kid #1 (voice) | Sandlot Kid #1 (voice) |
 Jason HarrisAnnouncer (voice) | Announcer (voice) |
 Ed HelmsHobo Louie (voice) | Hobo Louie (voice) |
 Ray IannicelliConductors / Umpire (voice) | Conductors / Umpire (voice) |
 Gideon JacobsBully Kid Tubby (voice) | Bully Kid Tubby (voice) |
| MMarcus MauriceWillie (voice) | Willie (voice) |
| AAmanda ParsonsEmily Irving (voice) | Emily Irving (voice) |
 Dana ReeveEmily Irving (voice) | Emily Irving (voice) |
 Will ReeveBig Kid (voice) | Big Kid (voice) |
| RRon TippeHobo Jack (voice) | Hobo Jack (voice) |
 Joe TorreYankees' Manager (voice) | Yankees' Manager (voice) |
 Forest WhitakerLonnie Brewster (voice) | Lonnie Brewster (voice) |
| CConor J. WhiteBully Kid Arnold (voice) | Bully Kid Arnold (voice) |
| RRochelle HogueAdditional Voices (voice) | Additional Voices (voice) |
 Sondra JamesAdditional Voices (voice) | Additional Voices (voice) |
| GGreta MartinAdditional Voices (voice) | Additional Voices (voice) |
| CChristie MoreauAdditional Voices (voice) | Additional Voices (voice) |
| SSean OliverAdditional Voices (voice) | Additional Voices (voice) |
