 Rob CorddryGary Supernova (voice) | Gary Supernova (voice) |
 Brendan FraserScorch Supernova (voice) | Scorch Supernova (voice) |
 Jessica AlbaLena (voice) | Lena (voice) |
 Steve ZahnHawk (voice) | Hawk (voice) |
 Sarah Jessica ParkerKira Supernova (voice) | Kira Supernova (voice) |
 Ricky GervaisMr Bing (voice) | Mr Bing (voice) |
 Gregg BinkleyRalph (voice) (uncredited) | Ralph (voice) (uncredited) |
 Sofía VergaraGabby (voice) | Gabby (voice) |
 Kaitlin Olson3D Movie Girl (voice) | 3D Movie Girl (voice) |
 Ashley EcksteinAlien (voice) | Alien (voice) |
 Craig RobinsonDoc (voice) | Doc (voice) |
 Jane LynchIo (voice) | Io (voice) |
 George LópezThurman (voice) | Thurman (voice) |
 Jonathan Morgan HeitKip Supernova (voice) | Kip Supernova (voice) |
 Chris ParnellHammer (voice) | Hammer (voice) |
 William ShatnerGeneral Shanker (voice) | General Shanker (voice) |
 Bob Bergen3D Movie Guy (voice) | 3D Movie Guy (voice) |
 Joshua RushYoung Shanker (voice) | Young Shanker (voice) |
 Doug AbrahamsHazmat / Baabian Citizen (voice) | Hazmat / Baabian Citizen (voice) |
 Sean KeninRadio Host (voice) | Radio Host (voice) |
 Bill HaderAnnouncer (voice) (uncredited) | Announcer (voice) (uncredited) |
