 Jane AlexanderEleanor Roosevelt | Eleanor Roosevelt |
 Edward HerrmannFranklin D. Roosevelt | Franklin D. Roosevelt |
 Priscilla PointerMissy LeHand | Missy LeHand |
| WWalter McGinnLouis Howe | Louis Howe |
 Rosemary MurphySara Delano Roosevelt | Sara Delano Roosevelt |
 Blair BrownAnna Roosevelt | Anna Roosevelt |
 Mark HarmonRobert Dunlap | Robert Dunlap |
 David HealyTheodore Roosevelt | Theodore Roosevelt |
 Peggy McCayGrace Tully | Grace Tully |
 Donald MoffatHarry Hopkins | Harry Hopkins |
| TToni DarnayMalvina Thompson | Malvina Thompson |
 John BealDr. Carr | Dr. Carr |
| BBarbara Smith ConradMarian Anderson (as Barbara Conrad) | Marian Anderson (as Barbara Conrad) |
 Morgan FarleyBill Plog | Bill Plog |
 Anna LeeLaura Delano | Laura Delano |
 Linda KelseyLucy Mercer | Lucy Mercer |
| CColin HamiltonIke Hoover | Ike Hoover |
 Ray BakerJames Roosevelt | James Roosevelt |
 Brian Patrick ClarkeJohn Roosevelt | John Roosevelt |
| DDon HowardElliot Roosevelt | Elliot Roosevelt |
 Joseph HackerFranklin D. Roosevelt Jr. | Franklin D. Roosevelt Jr. |
 Charles LampkinIrvin McDuffie | Irvin McDuffie |
 Lindsay CrouseNot listed | Not listed |
 Tina ColeSinger | Singer |
| CCathy ColeSinger | Singer |
 Ian AbercrombieWhiting (uncredited) | Whiting (uncredited) |
 Robert BanasChoreographer (uncredited) | Choreographer (uncredited) |
| DDouglas NelsonNewspaper Man (uncredited) | Newspaper Man (uncredited) |
 David LewisJustice Hughes | Justice Hughes |