 Dakota FanningEuphemia 'Effie' Gray | Euphemia 'Effie' Gray |
 Emma ThompsonLady Eastlake | Lady Eastlake |
 Greg WiseJohn Ruskin | John Ruskin |
 Tom SturridgeEverett Millais | Everett Millais |
 Robbie ColtraneDoctor | Doctor |
 Julie WaltersMargaret Cox Ruskin | Margaret Cox Ruskin |
 Derek JacobiTravers Twiss | Travers Twiss |
 Claudia CardinaleViscountess | Viscountess |
 David SuchetMr. Ruskin | Mr. Ruskin |
 James FoxSir Charles Eastlake | Sir Charles Eastlake |
 Patrick DoyleWedding Minister | Wedding Minister |
 Russell ToveyGeorge | George |
 Linda BassettAnna | Anna |
 Pip TorrensRoyal Academy / Times Journalist | Royal Academy / Times Journalist |
 Nicholas JonesDoctor Lee | Doctor Lee |
| JJoanna HoleMrs. McPhail (uncredited) | Mrs. McPhail (uncredited) |
 Riccardo ScamarcioRafael | Rafael |
| PPolly DartfordSophie Gray | Sophie Gray |
| TTom HerriottWilliam Holman Hunt | William Holman Hunt |
| SSam ChurchillDante Gabriel Rossetti | Dante Gabriel Rossetti |
| MMartin KeatmanThomas Woolner | Thomas Woolner |
| CChris HaggartWilliam Michael Rossetti | William Michael Rossetti |
 Alex BestJames Collinson | James Collinson |
| GGeorge LaingFrederic Stephens | Frederic Stephens |
| PPeter FarrMr. Gray | Mr. Gray |
| NNicola DraffanMrs. Gray | Mrs. Gray |
| SSaskia KeatmanLady Rondell | Lady Rondell |
| KKelly HealeyLady Dashwood | Lady Dashwood |
| FFrida BaranekDuchess di Alba | Duchess di Alba |
 Tigerlily HutchinsonYoung Effie, Borghese Gallery | Young Effie, Borghese Gallery |
