Eddie Murphy: One Night Only pays homage to Murphy's journey from a 15-year-old aspiring comedian, through the record-breaking Raw, which remains the highest grossing stand-up film of all time and featuring his indelible characters and impressions from Saturday Night Live including Buckwheat, Gumby, Mr. Robinson and James Brown.
| Actor | Role |
|---|---|
 Eddie MurphySelf | Self |
 Charlie MurphySelf | Self |
 Chris RockSelf | Self |
 Martin LawrenceSelf | Self |
 Jamie FoxxSelf | Self |
 Samuel L. JacksonSelf | Self |
 Tracy MorganSelf | Self |
 Arsenio HallSelf | Self |
 Keenen Ivory WayansSelf | Self |
 Tyler PerrySelf | Self |
 Brett RatnerSelf | Self |
 Jeffrey KatzenbergSelf | Self |
 Adam SandlerSelf | Self |
 Russell BrandSelf | Self |