Duetto takes place in 1965 and tells the story of 18-year-old Cora, a Brazilian from an Italian family who, after losing her dad in a tragic car accident, goes with her grandmother Lucia to Puglia, Italy, where her ancestral homestead still stands. Lucia, aiming to sell an old family land lot, reencounters her sister Sofia and her husband Gino, whom she hasn't spoken to in 40 years.
| Actor | Role |
|---|---|
 Giancarlo GianniniGino | Gino |
 Marieta SeveroLucia | Lucia |
 Luisa ArraesCora | Cora |
 Elisabetta De PaloSofia | Sofia |
 Maeve JinkingsIsabel | Isabel |
 Gabriel LeoneCarlo | Carlo |
 Michele MorroneMarcello Bianchini | Marcello Bianchini |
 Rodrigo LombardiMarcelo | Marcelo |
 Theresa FonsecaGiovanna | Giovanna |
| TThuany ParenteMirela Barini | Mirela Barini |
| AAlvise CamozziNot listed | Not listed |
 Cássio PandolphVittorio | Vittorio |
| ÁÁlvaro MottaBernardi | Bernardi |
| SSimon PetrachiNot listed | Not listed |
 Raffaele CasuccioNot listed | Not listed |
| PPietro BaranaNot listed | Not listed |
| MMarco MarfiaNot listed | Not listed |
| AAll MottaNot listed | Not listed |
| NNicola CaliaNot listed | Not listed |
 Isa SalmenIsla | Isla |
| BBarbara GianazzaNot listed | Not listed |
| EEli André CorrêaRecepcionista | Recepcionista |
| LLuiz Carlos ZigueFrancesco Teranza | Francesco Teranza |
| GGuido PucciarelliGuido | Guido |
 João GuesserEnzo Scorelli | Enzo Scorelli |
 Adriana BellongaPietra | Pietra |
| IIca BonfimDonatella Gualazzi | Donatella Gualazzi |
 Maggie R. SchneiderCantora Italiana | Cantora Italiana |