Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
| Actor | Role |
|---|---|
 Matt DillonBob | Bob |
 Kelly LynchDianne | Dianne |
 James RemarGentry | Gentry |
 James Le GrosRick | Rick |
 Heather GrahamNadine | Nadine |
 Beah RichardsDrug Counselor | Drug Counselor |
 Grace ZabriskieBob's Mother | Bob's Mother |
 Max PerlichDavid | David |
 William S. BurroughsTom the Priest | Tom the Priest |
 Eric HullDruggist | Druggist |
| JJohn KellyCop | Cop |
 George CatalanoTrousinski | Trousinski |
| JJanet BaumhoverNeighbor Lady | Neighbor Lady |
 Ted D'ArmsNeighbor Man | Neighbor Man |
| NNeal ThomasHalamer | Halamer |
| SStephen RutledgeHotel Manager | Hotel Manager |
| RRobert Lee PitchlynnHotel Clerk | Hotel Clerk |
| RRoger HancockMachinist | Machinist |
| MMichael ParkerCrying Boy | Crying Boy |
| RRay MongeAccomplice | Accomplice |
 Gus Van SantHimself (uncredited) | Himself (uncredited) |