 John BarrymoreDr. Henry Jekyll / Mr. Edward Hyde | Dr. Henry Jekyll / Mr. Edward Hyde |
 Brandon HurstSir George Carewe | Sir George Carewe |
 Martha MansfieldMillicent Carewe | Millicent Carewe |
 Charles LaneDr. Richard Lanyon | Dr. Richard Lanyon |
| CCecil ClovellyEdward Enfield | Edward Enfield |
 Nita NaldiMiss Gina | Miss Gina |
 Louis WolheimMusic Hall Proprietor | Music Hall Proprietor |
| AAlma AikenExtra (uncredited) | Extra (uncredited) |
| JJ. Malcolm DunnJohn Utterson (uncredited) | John Utterson (uncredited) |
 Ferdinand GottschalkOld Man at Table in Music Hall (uncredited) | Old Man at Table in Music Hall (uncredited) |
 Julia HurleyHyde's Landlady with Lamp (uncredited) | Hyde's Landlady with Lamp (uncredited) |
| JJack McHughStreet Kid - Raises Fist to Mr. Hyde (uncredited) | Street Kid - Raises Fist to Mr. Hyde (uncredited) |
| GGeorgie Drew MendumPatron in Music Hall (uncredited) | Patron in Music Hall (uncredited) |
| BBlanche RingWoman at Table with Old Man in Music Hall (uncredited) | Woman at Table with Old Man in Music Hall (uncredited) |
 May RobsonProstitute at Clinic (uncredited) | Prostitute at Clinic (uncredited) |
| GGeorge StevensJekyll's Butler Poole (uncredited) | Jekyll's Butler Poole (uncredited) |
 Edgard VarèsePoliceman (uncredited) | Policeman (uncredited) |
