 Johnny DeppDonnie Brasco / Joseph D. 'Joe' Pistone | Donnie Brasco / Joseph D. 'Joe' Pistone |
 Al PacinoBenjamin 'Lefty' Ruggiero | Benjamin 'Lefty' Ruggiero |
 Michael MadsenDominick 'Sonny Black' Napolitano | Dominick 'Sonny Black' Napolitano |
 Bruno KirbyNicholas 'Nicky' Santora | Nicholas 'Nicky' Santora |
 James RussoPaulie | Paulie |
 Anne HecheMaggie Pistone | Maggie Pistone |
 Željko IvanekTim Curley | Tim Curley |
 Brian TarantinaBruno | Bruno |
 Rocco SistoRichard 'Richie' Gazzo | Richard 'Richie' Gazzo |
 Zach GrenierDr. Berger | Dr. Berger |
 Gerry BeckerAgent Dean Blandford FBI | Agent Dean Blandford FBI |
 Robert MianoAlphonse 'Sonny Red' Indelicato | Alphonse 'Sonny Red' Indelicato |
 Paul GiamattiFBI Technician | FBI Technician |
 Gretchen MolSonny's Girlfriend | Sonny's Girlfriend |
 Tim Blake NelsonFBI Technician | FBI Technician |
 Walt MacPhersonSheriff | Sheriff |
 Ronnie FarerAnnette | Annette |
 Terry SerpicoStrip Club Owner | Strip Club Owner |
 Tony LipPhilip 'Philly Lucky' Giaccone | Philip 'Philly Lucky' Giaccone |
| GGeorge AngelicaBig Trin | Big Trin |
 Val AverySanto Trafficante Jr. | Santo Trafficante Jr. |
 Madison ArnoldJilly | Jilly |
| DDelanie FitzpatrickDaughter | Daughter |
 Katie SagonaDaughter | Daughter |
| SSara GoldDaughter | Daughter |
 Larry RomanoTommy | Tommy |
 James McCauleyFBI Agent | FBI Agent |
| JJames BulleitU.S. Attorney | U.S. Attorney |
 Andrew ParksHollman | Hollman |
| KKeenan ShimizuJapanese Maitre D' | Japanese Maitre D' |
