Dominick and Eugene are twins, but Dominick is a little bit slow due do an accident in his youth. They live together, with Dominick working as garbage man to put Eugene through medical school. Their relationship becomes strained when Eugene must decide between his devotion to his brother, or his need to go away to complete his training. Things are also not helped by Dominick's co-worker, or Eugene's budding romance.
| Actor | Role |
|---|---|
 Tom HulceDominick Luciano | Dominick Luciano |
 Ray LiottaEugene Luciano | Eugene Luciano |
 Jamie Lee CurtisJennifer Reston | Jennifer Reston |
 Todd GraffLarry Higgins | Larry Higgins |
 Bill CobbsJesse Johnson | Jesse Johnson |
 David StrathairnMartin Chernak | Martin Chernak |
| MMimi CecchiniMrs. Gianelli | Mrs. Gianelli |
 Robert LevineDr. Levinson | Dr. Levinson |
| TTommy SnelsireMikey Chernak | Mikey Chernak |
 Mary-Joan NegroTheresa Chernak | Theresa Chernak |
 Tom SignorelliFather T. | Father T. |