 Lionel AtwillDr. Jerry Xavier | Dr. Jerry Xavier |
 Fay WrayJoanne Xavier | Joanne Xavier |
 Lee TracyLee Taylor | Lee Taylor |
 Preston FosterDr. Wells | Dr. Wells |
 John WrayDr. Haines | Dr. Haines |
 Harry BeresfordDr. Duke | Dr. Duke |
 Arthur Edmund CareweDr. Rowitz | Dr. Rowitz |
 Leila BennettMamie | Mamie |
 Robert WarwickCommissioner Stevens | Commissioner Stevens |
| GGeorge RosenerOtto, Dr. Xavier's Butler | Otto, Dr. Xavier's Butler |
 Willard RobertsonDetective O'Halloran | Detective O'Halloran |
 Thomas E. JacksonDaily World Editor | Daily World Editor |
 Harry HolmanMike, Waterfront Policeman | Mike, Waterfront Policeman |
 Mae BuschCathouse Madame | Cathouse Madame |
 Tom DuganSheriff | Sheriff |
| RRaoul FreemanMorgue Detective (Uncredited) | Morgue Detective (Uncredited) |
 Selmer JacksonWillard Keefe, Daily World Night Editor (Uncredited) | Willard Keefe, Daily World Night Editor (Uncredited) |
| CCharles McMurphyDetective at Headquarters (Uncredited) | Detective at Headquarters (Uncredited) |
| KKy RobinsonMorgue Detective (Uncredited) | Morgue Detective (Uncredited) |
 Louise BeaversLouise (Uncredited) | Louise (Uncredited) |
