 Michael J. FoxBenjamin Stone | Benjamin Stone |
 Julie WarnerVialula (Lou) | Vialula (Lou) |
 Barnard HughesAurelius Hogue | Aurelius Hogue |
 Woody HarrelsonHank Gordon | Hank Gordon |
 David Ogden StiersMayor Nick Nicholson | Mayor Nick Nicholson |
 Frances SternhagenLillian, Welcoming Committee | Lillian, Welcoming Committee |
 George HamiltonDoctor Halberstrom | Doctor Halberstrom |
 Bridget FondaNancy Lee Nicholson | Nancy Lee Nicholson |
 Mel WinklerMelvin the Mechanic | Melvin the Mechanic |
 Helen MartinMaddie, Welcoming Committee | Maddie, Welcoming Committee |
 Roberts BlossomJudge Evans | Judge Evans |
| TTom LacyDeputy Cotton | Deputy Cotton |
 Macon McCalmanAubrey Draper | Aubrey Draper |
 Raye BirkSimon Tidwell, First Patient | Simon Tidwell, First Patient |
 Eyde ByrdeNurse Packer | Nurse Packer |
| WWilliam CowartLane, Melvin's Helper | Lane, Melvin's Helper |
 Amzie StricklandViolet, Welcoming Committee | Violet, Welcoming Committee |
 Time WintersKyle Owens | Kyle Owens |
 K.T. VogtMary Owens | Mary Owens |
 Jordan LundJohn Crawford | John Crawford |
| RRobert MunnsMortimer the Barber | Mortimer the Barber |
| DDouglas BrushMcClary | McClary |
 Barry SobelDr. Tommy Shulman | Dr. Tommy Shulman |
| AAmanda Junette DonatelliEmma, Lou's Daughter | Emma, Lou's Daughter |
 Billy GillespieZeb's Father | Zeb's Father |
| KKathy PolingZeb's Mother | Zeb's Mother |
| EEric BechtelZeb | Zeb |
 Cristi ConawayReceptionist at Halberstrom Clinic | Receptionist at Halberstrom Clinic |
 Kelly Jo MinterMulready | Mulready |
 Michael Caton-JonesL.A. Maitre D' | L.A. Maitre D' |
