 Joe RoganSelf - Host | Self - Host |
 Ralph AbrahamSelf - Mathematician | Self - Mathematician |
| JJoel BakstSelf - Rabbi | Self - Rabbi |
| SSteven BarkerSelf - Pharmacologist | Self - Pharmacologist |
| CCynthia GeistSelf - DMT Study Nurse | Self - DMT Study Nurse |
| SSusan BlumenthalSelf - DMT Volunteer | Self - DMT Volunteer |
| PPatricio DominguezSelf - DMT Volunteer | Self - DMT Volunteer |
| NNeal GoldsmithSelf - Psychologist | Self - Psychologist |
 Alex GreySelf - Artist | Self - Artist |
 Roland GriffithsSelf - Behavioral Pharmocologist | Self - Behavioral Pharmocologist |
| CCharles GrobSelf - Psychiatrist | Self - Psychiatrist |
| KKathleen HarrisonSelf - Ethnobotanist | Self - Ethnobotanist |
 Terence McKennaSelf - Writer & Cultural Commentator (archive footage) | Self - Writer & Cultural Commentator (archive footage) |
| EErik DavisSelf - Writer | Self - Writer |
 Graham HancockSelf - Writer | Self - Writer |
| JJames KentSelf - Writer | Self - Writer |
 Dennis J. McKennaSelf - Ethnopharmacologist | Self - Ethnopharmacologist |
 Ralph MetznerSelf - Psychologist | Self - Psychologist |
| CChristian MeuliSelf - DMT Volunteer, Family Physician | Self - DMT Volunteer, Family Physician |
 Jeremy NarbySelf - Anthropologist | Self - Anthropologist |
| AAndrew NewbergSelf - Radiologist | Self - Radiologist |
 David NicholsSelf - Medicinal Chemist | Self - Medicinal Chemist |
| DDaniel PinchbeckSelf - Writer | Self - Writer |
 Douglas RushkoffSelf - Writer | Self - Writer |
| SSpiros AntonopoulosSelf - DMT Volunteer, Yoga Student | Self - DMT Volunteer, Yoga Student |
| LLeanna StandishSelf - Naturopathic Physician | Self - Naturopathic Physician |
| AAndrew StoneSelf - DMT Volunteer, Software Developer | Self - DMT Volunteer, Software Developer |
 Rick StrassmanSelf - Psychiatrist | Self - Psychiatrist |
| RRobert WeiszSelf - DMT Volunteer, Clinical Psychiatrist | Self - DMT Volunteer, Clinical Psychiatrist |
| RRicardo AmaringoSelf | Self |
