Django arrives in the town of Santa Anna at the behest of a man named Sanders who'd been trying to buy safe passage for his cargo from a Mexican bandit named El Santo. Django finds that Sanders has been killed and that his rival, a man named Thompson, is now trying to deal with El Santo. Django, after a brief involvement with a beautiful young widow named Linda -- who has information on a lost gold mine -- becomes entangled in this situation by agreeing to escort a shipment through El Santo's territory.
| Actor | Role |
|---|---|
 George EastmanDjango | Django |
 Luciano RossiDr. Thompson | Dr. Thompson |
 Liana OrfeiLinda | Linda |
| MMimmo MaggioEl Santo | El Santo |
| DDomenico MaggioEl Santo (comme Mimmo Maggio) | El Santo (comme Mimmo Maggio) |
| PPeter HellmanRosson | Rosson |
| PPaul MarouSteve (as Paul Maru) | Steve (as Paul Maru) |
 Spartaco ConversiMiguel | Miguel |
| AAntonio TomahawkPedro | Pedro |
| FFederico BoidoCelui nerveux (comme Rik Boyd) | Celui nerveux (comme Rik Boyd) |
 Anna ManduchiMrs. Sanders | Mrs. Sanders |
 Maurizio MannoiaEl Santo's Bandit (uncredited) | El Santo's Bandit (uncredited) |
 Gerlando MartelliThompson's Henchman (uncredited) | Thompson's Henchman (uncredited) |