An academic obsessed with roadside attractions and his tv-star daughter stop at a small desert town to see the world's largest ice cream cone, where, because of an accident that spilled an unknown substance all over the highway, they are forced to spend a few days with the towns eccentric residents.
| Actor | Role |
|---|---|
 Kate HudsonSkye Davidson | Skye Davidson |
 Brendan Sexton IIIBlue Baxter | Blue Baxter |
 John HeardProf. Lance Davidson | Prof. Lance Davidson |
 Christina RicciEly Jackson | Ely Jackson |
 Casey AffleckPete Kepler | Pete Kepler |
 Sara GilbertSandy | Sandy |
 Ethan SupleeCale | Cale |
 Peter SarsgaardBilly Baxter | Billy Baxter |
 Lucinda JenneyCaroline Baxter | Caroline Baxter |
 Michael IronsideAgent Frank Bellows | Agent Frank Bellows |
 Daniel von BargenSheriff Jackson | Sheriff Jackson |
 Aunjanue Ellis-TaylorAgent Summers | Agent Summers |
| LLee HolmesDeputy Keeler | Deputy Keeler |
 Isidra VegaHaley Gordon | Haley Gordon |
 Rene RiveraDr. Gordon | Dr. Gordon |
 Fred SchneiderKBLU Radio DJ (voice) | KBLU Radio DJ (voice) |
 Liev SchreiberMickey Moonday (voice) | Mickey Moonday (voice) |
 Richmond ArquetteTruck Driver | Truck Driver |
| JJerry AgeeInsurance Agent | Insurance Agent |
 Ntare Guma Mbaho MwineAgent Green | Agent Green |